They are cosmetic actives with meaningful, if imperfect, evidence bases
How to supplement when B12 tests are high Be sure you remove all sources of synthetic cyanocobalamin from your diet (supplements & fortified foods) Consider supplementing with iodine, selenium, and molybdenum which helps activate B2 (a B12 transport helper) Consider supplementing with an active B2 form (Riboflavin-5-Phosphate) - a B12 transport cofactor Consider taking intrinsic factor which helps the gut better absorb B12 Consider pulsing 4.5 mg of lithium orotate (2-3x per week) - helps the B12 transport Only supplement with bioidentical active B12 forms - hydroxocobalamin, methylcobalamin, adenosylcobalamin I know my specific COMT & VDR Taq gene details
Its small size results in favorable penetration in tissue models
While dietary supplements are less tightly regulated than drugs, the FDA still requires them to only contain ingredients found on a list of approved substances
Comment: A few commenters expressed support for CMS' proposal to augment the prescriber NPI and MPN file by using NPI when the NPI is listed in the 340B OPAIS database but an MPN is not
Combine with topical GHK-Cu serum on the scalp for best results
