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In a 68-week placebo-controlled trial, once-weekly semaglutide (Ozempic, Wegovy) injections in people with obesity and moderate knee osteoarthritis produced significantly greater reductions in body weight along with significant improvements in pain scores and better physical function

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Testosterone: The gradual decline of testosterone (yes, women have it too!) can cause a loss of lean muscle mass

Starting them at the same time could make those symptoms worse

doi: 10.1007/s40120-025-00724-y

Less common but potentially serious risks may include pancreatitis (inflammation of the pancreas), gallbladder problems, kidney damage, allergic reactions, and thyroid tumors