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This analysis further assessed whether the increase in DRP was a GLP-1 specific effect, or rather caused by a robust and early glucose lowering as suggested by several other studies, where acute and large reductions in glucose concentrations may initially and transiently worsen DRP, yet prevent or delay onset or progression of DRP in the long term (123128)

And almost 17% of the visits were for very low blood sugar (hypoglycemia, a potentially life-threatening condition) - an unexpected finding

de Sousa RT, Zarate CA, Zanetti MV, Costa AC, Talib LL, Gattaz WF, et al

Probiotics support the microbiome

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measurable weight change builds over weeks to months, with the trial endpoint measured at 68 weeks