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In addition to stating that estimands should be used, the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) guidelines also emphasize the importance of considering intercurrent events when defining the scientific question of interest and underline key principles for handling missing data [3]

However, using laxatives requires careful consideration

This dose-tolerability relationship provides useful guidance for clinical protocol development

we look at how that data translates into your daily life

Cell 168, 960976

Drugdrug interaction study between a novel oral ibandronate formulation and metformin