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This blockage in autophagic flux ultimately leads to BAX/BAK oligomerization, activation of Caspase-3-mediated apoptosis, as verified in a POF model rat (Zhou et al., 2023)

Nature (2020) 578(7796):5939

survodutide, a dual glucagon and GLP-1 receptor agonist

The best part

Hematoxylin and eosin (H&E) staining, along with Nissl body labeling, were utilized to assess neuronal integrity

As a long-term consequence of ligature-induced periodontitis, not only tissue gingival inflammation measured by extravasation increased but there was also a considerable bone loss in the periodontium