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Nature 583 , 282285 (2020)

Preclinical research suggests that GLP-1 receptor activation may strengthen tight junctions between intestinal epithelial cells, reducing the translocation of bacterial products (like lipopolysaccharide) that trigger systemic immune activation

Coli are a large group of bacteria found naturally in the environment but also are common natural inhabitants of the human gut

Given the short half-life, twice-daily dosing provides additional exposure compared to once-daily protocols at the same total dose