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TABLE 1 Therapeutic mechanisms and targets of natural products targeting mitochondria in kidney diseases

A recently discovered route of NAD + synthesis utilizes reduced forms of NR and NMN, namely dihydronicotinamide riboside (NRH) and dihydronicotinamide mononucleotide (NMNH)

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Whether prolonged, systemic treatments with reductive agents that cross the blood brain barrier would prove to be an effective preventive treatment for patients at high risk remains to be established

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Suitable for quantitative redox assays, enzyme kinetic studies, and drug-induced cytotoxicity models