High Protein Intake : Protein is essential for muscle maintenance, especially during calorie reduction
Extended-duration effects of GLP-1 RAs and multi-agonists on liver-associated outcomes involving cirrhosis development, HCC incidence, and death from hepatic causes are being elucidated through ongoing observational studies and long-term trial extensions [65-70]
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Abstract Glucagon-like peptide-1 receptor agonists (GLP-1RAs)along with the dual glucose-dependent insulinotropic polypeptide (GIP)/GLP-1RA tirzepatideare widely acknowledged for their efficacy in managing both type 2 diabetes mellitus and obesity, with expanding indications in cardiometabolic risk reduction
In high-GDP countries, increased public and private healthcare spending allows for broader access to advanced therapies like GLP-1 receptor agonists
Relevant studies have found that exendin-4 could mediate the neuroprotective effect on -aminobutyric acid neurons in the piriform cortex and striatum and play a neuroprotective role in a cAMP/PKA- and PI3K/AKT-dependent manner after stroke (84, 85)
