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Introduction Uterine fibroids (UFs), also known as leiomyoma, are common benign gynecological tumors that proliferate from the myometrial smooth muscle cells into discrete masses ( The incidence of UF was reported as 1.278% and 3.745% in Asia and African American women per year, respectively ( The etiology and/or the exact cause of UF are still unclear

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Endogenous tissue inhibitors of MMPs (TIMPs) play a crucial role in safeguarding the BBB from disruption after ischemia by regulating the activities of MMPs [198]