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It is indigenous to Northwest India, which remains its primary production region, but it is also found in Madagascar, Northeast Africa, South Africa, Tropical Asia, Latin America, and Southwest Asia (Meireles et al

The activity of BCKD kinase is itself regulated by phosphorylation, being phosphorylated on Tyr 246 (Y246) by the SRC tyrosine kinase

However, it can be depleted owing to aging, stress, poor nutrition, pollution, alcohol consumption, and diseases