[9] Transient itching or rash has been noted in some cases, possibly indicating a mild sensitivity reaction
The convergence of these direct and indirect mechanisms results in the attenuation of ECM accumulation and preservation of renal structure, offering a multi-layered strategy for delaying the progression of DKD
However, pharmacokinetic studies suggest that these comorbidities do not affect the pharmacokinetics of oral semaglutide, and based on the observed safety profiles, no dose adjustments are recommended [68, 69]
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