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263 Individuals who are HLA-DQ2 or HLA-DQ8 positive (at risk for celiac disease but not diagnosed with the condition) have also been shown to have altered bowel movement frequency and increased intestinal permeability with gluten consumption and may want to avoid gluten
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The Endocrine Society's 2022 clinical practice guideline on type 2 diabetes management states: "Clinicians should systematically review concomitant medications that affect renal function or compete for renal tubular secretion when prescribing metformin" [15]
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