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doi: 10.1542/peds.2011-1106 41 MeltzerD
Extended Activity: Due to reduced binding to IGF-binding proteins, IGF-1 LR3 may produce more prolonged receptor engagement than equivalent amounts of native IGF-1 in experimental systems, allowing for detailed study of dosetime relationships and cumulative effects on cell populations
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Participants treated with Rybelsus also experienced greater reductions in fasting plasma glucose than those treated with Januvia across the PIONEER roundtable series of trials
mucosal barrier repair programs may be most directly applicable in UC and inflammatory luminal CD, while the trophic and proliferative effects of GLP-2 require more cautious evaluation in stricturing or penetrating CD given the fibrosis considerations discussed above
High costs, linked to complex peptide synthesis manufacturing, create significant market challenges
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