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Scientific References Hydroxocobalamin 1mg/ml Solution for Injection SmPC (emc)

Keeping hydrated can aid in expelling these toxins faster

Split dosing may help if: single morning dose produces effects that fade by afternoon, you are using higher doses (450-500mcg) where sustained levels may help, or evening administration fits your schedule better than early morning

It seems you may need high B12 supplementation and to stop any folate supplements for a while

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