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Paget observed that primary tumor cells of a given type of cancer preferentially metastasized to one or more particular distant organ sites, detectable metastases only developed at those sites (soils) where the tumor cells (seeds) were adapted for survival and proliferation [21]

even lower exposure beat placebo for weight loss in early trials. The 2.4 mg maintenance dose sits on the shoulder of the effect curve rather than at a hard ceiling

Costa and colleagues confirmed the translocation of gut-associated bacteria to pancreatic lymph nodes increased the development of T1D-associated symptoms (Costa et al

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doi: 10.6004/jnccn.2011.0016 151 GradisharWJAndersonBOBlairSLBursteinHJCyrAEliasADet al

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