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Therefore, innovative strategies targeting these specific mechanisms are needed to improve the efficacy and tolerability of ADCs in autoimmune diseases

(2015) 10:e134768

Calcium homeostasis dysregulation impacts A aggregation, tau hyperphosphorylation, synaptic damage, neuronal apoptosis, mitochondrial dysfunction, oxidative stress, and neuroinflammation [69,70,71,72,73,74,75]

This may result in impaired tissue repair and regeneration and a decline in immune function

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It is not known the extent to which the increased risk is due to changes in the brain after an initial concussion that may make it more vulnerable to future impacts as opposed to factors (e.g., playing style, position, musculature) that might make an individual more susceptible to concussion in general