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Patients taking levothyroxine should not attempt to adjust thyroid dose based on weight loss or appetite changes alone

2006 Dec;291(6):E1290-4

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"Integrative Therapies During and After Breast Cancer Treatment: ASCO Endorsement of the SIO Clinical Practice Guideline." Journal of Clinical Oncology 36(25): 2647-2655

It's the strongest precedent for dose-splitting in peptide therapy

(1990) New colorimetric cytotoxicity assay for anticancer-drug screening