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Theres starting low and then staying low

PMID: 41144841 Phytomedicine Baohuoside I induces GSDME-dependent pyroptosis and synergistically inhibits lung adenocarcinoma with cisplatin

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In patients with type 2 diabetes mellitus, metagenomic analyses reveal that GLP-1RAs induce structural and functional remodeling of gut microbial communities, ameliorating dysbiosis and improving host metabolic homeostasis (Shang et al., 2021)

It also lowers the chance of side effects

Rodent thyroid C-cells respond to GLP-1 stimulation in a way that human C-cells largely do not