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The other is it can break down in stomach acid, requiring the body to put it back together (which is nutrient intensive)

The subsequent production of inflammatory cytokines, such as IL-1, IL-6, and TNF-, by these nociceptive free endings elicit spontaneous, repetitive action potentials in sensory afferents

These flavonols are typically conjugated with sugars and organic acids, with glycosylation most frequently occurring at position 3 of the C-ring

Terwilliger, T

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Lammi, Carmen, and Anna Arnoldi