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Impaired BBB integrity Postmortem studies of AD patients and animal models have revealed cellular infiltration, including red blood cells [139], macrophages [140], and neutrophils [141], as well as capillary leakage of blood-derived components such as fibrin(ogen), IgG, albumin, thrombin, and hemosiderin [142,143,144,145]

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Advanced glycation end-products increase the production of fibronectin in pericytes via a similar upregulation of autocrine transforming growth factor- secretion by pericytes [85]

M., Sliz, J., Isermann, P., Denais, C., & Lammerding, J