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Within the brain, vascular dysfunction, pathological alterations in the cellular environment, and microcirculatory hypoxia frequently act as instigators of neuroinflammation, often interconnecting in a complex web [103,104,105]
Effect of vitamin D supplementation on serum lipid profiles: a systematic review and meta-analysis
Endothelial dysfunction, vascular resistance, hypertension, and arterial wall inflammation are more likely to occur in patients with pre-existing microvascular damage, such as that caused by insulin resistance (23)
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Clinical evidence: in a cohort study involving 4,125 elderly individuals, higher cereal-derived RS intake (15 g/day) was associated with a 28% reduction in serum IL-6 levels and a 35% reduction in TNF- levels compared to low-RS intake ( 90%sufficient to meet 25% of daily protein requirements and support tryptophan (serotonin precursor) and tyrosine (dopamine precursor) supply (304)
