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Exclusion criteria The presence of serious somatic disorders, substance abuse except for cigarettes and caffeine, and history of high mood (mania or hypomania), mental dysfunction, dementia, acute psychiatric disorders according to the psychiatrist, and medication that causes depression in the patient were excluded from the study
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The physiochemical properties of D-Nle-Tyr-Ile-NH-(CH 2 ) 5 -CONH 2 were estimated following modeling with ADMET Predictor software