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In vitro studies have further confirmed that the lipid peroxidation product 4-HNE promotes the proliferation of PKD1-mutant cells and cyst growth via serine/threonine protein kinase, ribosomal protein S6, signal transducer and activator of transcription 3, and retinoblastoma tumor suppressor pathways (270)

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Graph generated by Claude from Excel spreadsheet and uploaded to GitHub

The excessive accumulation of subcutaneous adipose tissue is closely related to metabolic syndrome, cardiovascular diseases, etc

Concerns exist regarding potential direct passage into the bloodstream via gut tight junctions, bypassing normal digestive processes