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As shown in Figure 2D, the HOMA-IR score was significantly elevated by 2-fold ( p = 0.002) and 1.2-fold ( p = 0.007) in the GDM group at GD4 and GD18, respectively, as compared with the NPC group, whereas it was reduced significantly in the HBN group by 0.38-fold ( p = 0.04) and non-significantly in the LBN, LBF, and HBF groups by 0.2-fold ( p = 0.4), 0.07-fold ( p = 0.1), and 0.26-fold ( p = 0.17), respectively, at GD18 as compared with the GMD group

657 Importantly, intraventricular injection of Fer-1 significantly decreases iron deposition and neuronal degeneration, improving motor and cognitive function