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Modulating these cells regulates immune overactivity

GCGR activation, represented in green, is unique in that glucagon receptors are robustly expressed on hepatocytes, enabling direct liver-directed metabolic effects - a mechanistic feature absent from both GLP-1R and GIPR signaling

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To view a copy of this licence, visit About this article Cite this article Murphy, A., Shyanti, R.K

While our study demonstrated sustained weight loss over a median follow-up of 1 year, longer-term data are needed to assess the durability of these outcomes