why am i gaining weight with semaglutide for loss A Comprehensive Review on Weight

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However, discontinuing semaglutide may lead to weight regain, emphasizing the importance of adopting lifestyle changes for lasting weight control

And in many ways, it is

A large-scale genome-wide association study published in Nature in April 2026, conducted by 23andMe researchers using data from 27,885 GLP-1 medication users, identified a specific variant in the GLP1R gene the gene that encodes the primary receptor these drugs target associated with differential weight loss efficacy

The main function of WAT is to store excess energy in the form of fatty acids (TGs) or to release glycerol and FFAs as energy reservoirs to fuel effector organs, skeletal muscle and BAT when required [49]

Early research shows that semaglutide may benefit people with: Type 2 diabetes Heart disease Fatty liver disease High cholesterol High blood pressure This helpful medication works by curbing appetite and improving blood sugar