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In patients with pathological cardiac remodeling, cardiac lipid oxidation and the TCA cycle are inhibited, glycolysis is enhanced but glucose oxidation is unchanged or reduced, and the lack of energy supply further leads to HF 13,30

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Ethics declarations Conflict of interest During the peer review process the manufacturer of the agent under review was offered an opportunity to comment on the article

doi: 10.1111/j.1439-0396.2007.00752.x 45