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Activation of the receptors induces adenylate cyclase activation via coupling to Gs proteins, leading to elevated intracellular cyclic AMP (cAMP) production and activation of protein kinase Adependent signal transduction cascades

doi: 10.3390/nu11102315

This inhibition leads to increased insulin secretion and reduced glucagon levels by preventing the degradation of these hormones

Only small amounts of drug are released at a time, so potent drugs are better suited to this route of administration if systemic effects are required

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