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GI changes (constipation or diarrhea) are more often linked to B12 deficiency or underlying gut conditions that also impair B12 absorption

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While UK healthcare professionals can, in exceptional circumstances, prescribe unlicensed medicines under the MHRA 'specials' framework, this would rarely be appropriate for ED given the availability of licensed, evidence-based alternatives

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Researchers should always consider factors such as: Manufacturing standards Purity testing Batch consistency Independent verification where available High-quality research materials help improve reproducibility and reliability across scientific investigations

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