A further clinical trial called SELECT found that Wegovy produced clinically significant weight loss after 208 weeks
Cardiovascular studies with semaglutide rarely measure barrier integrity or microbial products, while reports on incretin-mediated barrier improvement seldom track myocardial remodeling within the same experiment 14,15,17
However, the drug was subsequently overtaken by Pfizers Lipitor (FDA-approved in 1996), which generated ~$100B in sales from 1992 to 2017
The American Diabetes Association explicitly warns that very low-calorie diets, defined as fewer than 800 calories daily, should only be undertaken under strict medical oversight with supplementation and monitoring
Therefore, you should not plan to conceive while on semaglutide
If you are taking Ozempic and have questions or concerns about changes in your sexual function or libido, it is appropriate to discuss these with your GP or diabetes specialist nurse