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We noted a significant increase in the action potential (AP) firing frequency in response to Ex-4c (from 2.80.3 to 3.60.4 Hz, n =44, P =0.002, paired t test), which further supported the excitatory effects of Ex-4c on arcuate POMC neurons (Supplemental Fig

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Higher doses increase appetite suppression but do not proportionally accelerate weight lossmost clinical benefit occurs at 1.0-2.4mg weekly, with diminishing returns above that

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The use of this smart system improved bioavailability, skin permeation, and antibacterial and anti-inflammatory activity in vitro, in vivo, and ex vivo conditions

Regulatory guidance and clinical practice recommend stopping GLP-1 agonists at least two months before planned pregnancy to allow adequate washout