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SR18 exhibited an average hydrodynamic diameter of 4.001 nm with a polydispersity index (PDI) of 0.2289, indicating a relatively uniform and predominantly monomeric population in 1 X PBS, compared to 10 M BSA (hydrodynamic diameter 7.631 nm and PDI 0.1645) as shown in Supplementary Figure S5
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Additionally, L-carnitine was orally administered to APOE-TR mice and its metabolism in the periphery and the brain evaluated (Figure 1)
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They must be conjugated to carnitine by carnitine palmitoyltransferase I (CPT-I) on the outer mitochondrial membrane to form acylcarnitine, transported across the inner membrane by carnitine-acylcarnitine translocase (CACT), and then released by carnitine palmitoyltransferase II (CPT-II) on the inner membrane for entry into beta-oxidation
This specific liquid ratio yields a clean concentration, making it easy to withdraw precise individual micrograms during testing
Context Dependent: Results occurred under specific study protocols
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