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in 2014 and in Canada in 2018

To increase the plasma half-life by avoiding renal elimination, GLP-1 analogs were modified by adding acyl groups (liraglutide and semaglutide) or large molecules such as albumin (albiglutide) and the Fc portion of IgG (dulaglutide)

November 16, 2023

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For many people, 8 to 12 weeks of manageable diarrhea is an acceptable trade-off for significantly better outcomes