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Ongoing dose adjustments Your provider can titrate your dose over time based on how you respond and tolerate it

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Because while semaglutide does not cause UTIs the way SGLT-2 inhibitors do, it creates several physiological changes that can shift urinary health in subtle but meaningful ways

It stimulates insulin release, effectively lowering blood sugar levels, especially after meals

doi: 10.1146/annurev-psych-010418-102936

Semaglutide works by slowing stomach emptying and signaling fullness to your brain, but this mechanism sometimes triggers nausea, vomiting, or constipation during the first 48 weeks