However, when GLP-1 receptor agonists are used in combination with insulin or sulphonylureas, the risk of hypoglycaemia increases, and dose reduction of these agents may be necessary
Currently, NICE guidance does not specifically address the use of GLP-1 receptor agonists in post-bariatric surgery patients , as this represents an evolving area of clinical practice
The structure-activity relationship (SAR) studies conducted by Chugai and subsequently by Eli Lilly explored modifications across the molecule's three principal domains: the tetrahydropyran ring system, the indazole heterocycle, and the substituted phenyl ring
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Barcia C, Bautista V, Sanchez-Bahillo A, Fernandez-Villalba E, Faucheux B, Poza y Poza M, et al