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The US hazard ratios shown above come from separate 12-month obesity cohorts for incident and recurrent alcohol use disorder, with separate type 2 diabetes cohorts used as replications

Severe hypogonadism: Men with very low testosterone due to primary testicular failure or other specific causes may not see full recovery with weight loss alone

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Of these trials, 2 were monotherapy (12 weeks) and 1 was adjunct therapy (3 weeks) to either lithium or divalproex

For people using insulin pens, there is very limited support beyond basic logbook apps and simple bolus calculators