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Clinical trial protocols from the Phase 2 NEJM study used a gradual escalation approach, starting at low doses and increasing every four weeks

For example, it may have been tested in an animal model, but not tested in a really rigorous double-blind clinical trial, which takes 10 to 15 years. She estimates that the entire process for bringing a drug from the lab to the market can cost about $2 billion

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Some patients may not even realize that they have small fractures in the vertebrae that are irritating their sciatic nerve

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