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Rescuing IOC with amlodipine in the animal model As an L-type Ca 2+ channel blocker, amlodipine can reduce the entry of non-transferrin-bound iron (Fe 2+ ) via L-type Ca 2+ channels, resulting in lower levels of cardiac iron and reduced oxidative stress in cardiac tissue

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For patients new to GLP-1 therapy or those with sensitive systems, microdosing offers a gentler introduction