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3D Variability analysis reveals differences in the GLP-1 ECD and G s AHD dynamics in the presence of different agonists
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The closed conformation of the inactive GLP-1R results in partial solvent protection of the hydrophobic ECD binding site, which is considered energetically favorable for an apo-state compared to an open conformation with full solvent exposure of the binding site
E., Beall, C., Pickering, A