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Human clinical trial data remains limited, but the mechanistic and preclinical evidence base is stronger for gut-related peptides than for most other peptide research categories

Hyperoxia during reperfusion is a factor in reperfusion injury

Mitochondrial superoxide radical formation is controlled by electron bifurcation to the high and low potential pathways

The IGF-1 pathway will lead to further oxidative stress

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While, down-regulation of the transporter directly confers resistance against the drug, via decreasing the intracellular platinum concentration (Kunii et al., 2015)