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One option is established and regulated for approved uses

Three weeks later, intraperitoneal injection of clozapine-N-oxide (CNO, a ligand of the chemogenetic designer receptor) at 1 h after morphine administration, which significantly increased both the output and water content of feces in hM3Dq-expressing mice compared to mCherry-expressing control mice (Fig

This contributes to overall cellular health and longevity

This step might involve acid-base catalysis by the active-site cysteinyl thiolate (which could explain an effect of the second cysteinyl residue), and/or the conserved lysine residue, yielding GS in analogy to glutathione transferases (Fig

This suggests the change is concentrated closer to the skin surface than to bone