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The European Medicines Agency issued a 2024 notice stating no evidence of association (Ruggiero et al., 2024)
Oestrogen acts as a primary regulator of metabolic health, and its withdrawal triggers a cascade of physiological shifts that prioritise fat storage over energy expenditure
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However, most trials recruited relatively healthy, non-drinking or light-drinking populations, so data specifically examining heavy drinkers on GLP-1 therapy is limited
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