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Moreover, GLP-1R-mediated EGFR transactivation activates the Ras/Raf/MEK/ERK axis, promoting -cell regeneration, angiogenesis in ischemic myocardium, and neuroprotection via dopaminergic neuron preservation and inflammation mitigation [39]

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[DOI] [PubMed] [Google Scholar] 56.Mann J.F., Fonseca V., Mosenzon O., Raz I., Goldman B., Idorn T., von Scholten B.J., Poulter N.R., LEADER Publication Committee on behalf of the LEADER Trial Investigators Effects of liraglutide versus placebo on cardiovascular events in patients with type 2 di-abetes mellitus and chronic kidney disease: Results from the LEADER trial

If appropriate, tirzepatide is prescribed with structured dosing instructions

J., Yang, L., Deng, L