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The primary outcome was the change in motor and non-motor symptoms as measured by the Unified Parkinsons Disease Rating Scale (UPDRS) and were interpreted using minimal clinically important difference (MCID) thresholds

J V Gobburu, et al

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Analyses of centella material put Asiatic Acid reported in the range of 0.2-3% of the extract

These mechanisms can be classified under two main functional categories: (a) upregulation of the sense gene through direct interactions with the sense gene mRNA transcript, and (b) upregulation of the sense gene through ASO-mediated inhibition of the NAT