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While there arent studies that compare the two, theyre very similar

Methacrylate-based microparticles have also been used in protein therapeutic formulations (Naha et al, Journal ofMicroencapsulation4 Feb., 2008 (online publication))

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Microneedling, where used as a penetration aid, adds its own local risks (transient redness, pinpoint bleeding) independent of the peptide