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Similarly, diverse situation existed in other researches as a study did not find evidence of an association between the MTHFR TT genotype and depression in a depression cohort 76

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The commenter also recommended re-specifying the measure to remove the FOTO Lumbar PRO-PM and instead use an alternative modern measurement science-based PRO-PM that has fewer proprietary restrictions on interoperability and use within HIT systems, such as the PROMIS Physical Function or the PROMIS Pain Interference

doi:10.1038/srep18039 49

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