Incretin mimetics, which include the GLP1 receptor agonist semaglutide and the GLP1/glucose-dependent insulinotropic polypeptide (GIP) receptor co-agonist tirzepatide, are anti-obesity medications associated with substantial and sustained weight loss in patients with obesity by delaying gastric emptying thereby reducing appetite and food intake
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This causes ghrelin to rise and leptin to fall
[DOI] [PubMed] [Google Scholar] 175.Orskov C, Holst JJ, Nielsen C
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