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Although red blood cells lack mitochondria, hepatocytes exhibit altered OXPHOS and tricarboxylic acid (TCA) cycle activity upon parasite infection ( Plasmodium infection decreases host mitochondrial respiration while increasing glycolytic flux, mirroring the Warburg-like effect seen in cancer cells (Nair et al., 2023)

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Doses of pyridoxine as low as 5-10 mg can antagonize levodopas effect if carbidopa is not present, so caution is warranted and any supplemental B beyond the nutritional dose should be under medical guidance

Leydig cell dysfunction might result in reduced testosterone levels

The landscape shifted in November 2025