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This difference has a direct consequence for how the protocol is structured

In the placebo group, the rate was close to 0,7%

[13] The slow-transit constipation is due to decreased number of interstitial cells of Cajal (ICC) and alteration of myenteric plexus neurons which secretes substance P

Caroline Apovian, then at Boston University School of Medicine, noted in a 2015 review of anti-obesity pharmacotherapy that "clinicians must monitor nutritional intake when combining agents that independently reduce appetite, particularly when one agent carries seizure liability" [8]

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Zhang S, Jiang S, Wang H, Di W, Deng C, Jin Z, et al