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The drug was approved based on research showing that 63 percent of people who took semaglutide cleared their MASH within 72 weeks compared to 34 percent of people taking a placebo

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[112] Patients of reproductive age should be informed about potential hormonal effects, and periodic monitoring may be appropriate for patients receiving long-term treatment

Understanding how these hormones function naturally has prompted interest in whether dietary supplements or lifestyle interventions might support their endogenous production or activity

Biochem Soc Trans 2014

A patient needing 120 mg/mL, or a combination with anastrozole to manage estradiol conversion, requires compounding